Hydrochloric Acid → HCID 11645783, compound

HRID 2299212Notes

Reaction equation

HRID 2299212 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[NH:9][S:10]([CH:13]1[C:18]([C:19]([O-:21])=[O:20])=[CH:17][CH2:16][CH2:15][CH2:14]1)(=[O:12])=[O:11].[Na+].Cl>O>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[NH:9][S:10]([CH:13]1[C:18]([C:19]([OH:21])=[O:20])=[CH:17][CH2:16][CH2:15][CH2:14]1)(=[O:11])=[O:12]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 23684386HCID 23684386, compound

Product 1

HCID 11645783HCID 11645783, compoundYield 98%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Sodium 6-[N-(2,4difluorophenyl)sulfamoyl]-1-cyclohexene-1-carboxylate (0.48 g) was dissolved in water (100 ml) and adjusted at pH 1 to 2 with 1N HCl and then extracted with ethyl acetate (100 ml). The ethyl acetate layer was washed with water (100 ml×2) and dried over anhydrous magnesium sulfate and then the solvent was distilled off under reduced pressure. The residue was crystallized from diisopropyl ether to obtain 6-[N-(2,4-difluorophenyl)sulfamoyl]-1-cyclohexene-1-carboxylic acid (0.44 g) as white powdery crystals.

Workup

  1. extractionextracted with ethyl acetate (100 ml)
  2. washThe ethyl acetate layer was washed with water (100 ml×2)
  3. dry with materialdried over anhydrous magnesium sulfate
  4. distillationthe solvent was distilled off under reduced pressure
  5. customThe residue was crystallized from diisopropyl ether

Sources & evidence

ORD record
ord-82d6b904a8904048b50c41616b5f348b
Source dataset
uspto-grants-2002_12
Patent number
US06495604B1

Reaction notes

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