Potassium Carbonate → HCID 22568991, compound

HRID 2299512Notes

Reaction equation

HRID 2299512 reaction equation
[CH:1]1([N:4]([CH2:19][CH3:20])[CH2:5][C:6]2[CH:11]=[CH:10][C:9]([C:12]#[C:13][Si](C)(C)C)=[CH:8][C:7]=2[CH3:18])[CH2:3][CH2:2]1.C(=O)([O-])[O-].[K+].[K+]>CO>[CH:1]1([N:4]([CH2:19][CH3:20])[CH2:5][C:6]2[CH:11]=[CH:10][C:9]([C:12]#[CH:13])=[CH:8][C:7]=2[CH3:18])[CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 22568965Cyclopropyl-ethyl-(2-methyl-4-trimethylsilanylethynyl-benzyl)-amine2×

Product 1

HCID 22568991HCID 22568991, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Using General Procedure E; cyclopropyl-ethyl-(2-methyl-4-trimethylsilanylethynyl-benzyl)-amine (Intermediate 160, 650.0 mg, 2.30 mmols) in methanol (10 mL) was treated with potassium carbonate (100.0 mg, 0.72 mmol) and stirred overnight at ambient temperature. The crude alkyne (495 mg, 99%) was used directly in the next reaction.

Sources & evidence

ORD record
ord-f780108f62f045518a3540b412cd1c46
Source dataset
uspto-grants-2002_12
Patent number
US06495552B2

Reaction notes

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