Leucine methyl ester hydrochloride → HCID 15484847, compound

HRID 2299538Notes

Reaction equation

HRID 2299538 reaction equation
Cl.[CH3:2][O:3][C:4](=[O:11])[C@H:5]([CH2:7][CH:8]([CH3:10])[CH3:9])[NH2:6].[Cl:12][C:13]1[CH:14]=[C:15]([NH:20][CH:21]([C:23](O)=[O:24])[CH3:22])[CH:16]=[CH:17][C:18]=1[Cl:19]>CCOC(C)=O>[CH3:2][O:3][C:4](=[O:11])[C@H:5]([CH2:7][CH:8]([CH3:10])[CH3:9])[NH:6][C:23](=[O:24])[C@H:21]([CH3:22])[NH:20][C:15]1[CH:16]=[CH:17][C:18]([Cl:19])=[C:13]([Cl:12])[CH:14]=1

Participants

4

Reactant 2

HCID 2723695Leucine methyl ester hydrochlorideHCID 69164262-(3,4-Dichloro-phenylamino)-propionic Acid

Product 1

HCID 15484847HCID 15484847, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

Following General Procedure D and using L-leucine methyl ester hydrochloride (Sigma) and N-(3,4-dichlorophenyl)-D,L-alanine (from Example A above), the title compound was prepared as a solid (mp=120-132° C.). The reaction was monitored by tlc (Rf=0.49 in 1:1 EtOAc:Hexanes) and the product was purified by flash chromatography using 1:1 EtOAc:Hexanes as the eluent.

Workup

  1. customthe product was purified by flash chromatography

Sources & evidence

ORD record
ord-c6e38a7742d64e658b81a0e7e9b5af2d
Source dataset
uspto-grants-2002_12
Patent number
US06495693B2

Reaction notes

Loading…