Ammonium Hydroxide → (2S)-(-)-1-Amino-3-phenoxy-2-propanol

HRID 2299630Notes

Reaction equation

HRID 2299630 reaction equation
[O:1]([CH2:8][C@H:9]1[O:11][CH2:10]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[NH4+:13]>C(O)C>[NH2:13][CH2:10][C@H:9]([OH:11])[CH2:8][O:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 14923Ammonium HydroxideHCID 1534345(2S)-2-(phenoxymethyl)oxirane

Product 1

HCID 1133101(2S)-(-)-1-Amino-3-phenoxy-2-propanol

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A stirred solution of (2S)-1-phenoxy-2,3-epoxypropane (1.0 g) and concentrated ammonium hydroxide (10 ml) in ethanol (10 ml) was sealed up at room temperature for 12 hours. The mixture was evaporated in vacuo and dried to give (2S)-1-amino-3-phenoxy-2-propanol (1.1 g).

Workup

  1. customThe mixture was evaporated in vacuo
  2. customdried

Sources & evidence

ORD record
ord-8d90f494aca748ca814d7b380f61ec3b
Source dataset
uspto-grants-2002_12
Patent number
US06495546B1

Reaction notes

Loading…