Hydrochloric Acid → HCID 69330106, compound

HRID 2299685Notes

Reaction equation

HRID 2299685 reaction equation
[OH:1][C@H:2]([CH2:27][O:28][C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1)[CH2:3][N:4](C(OC(C)(C)C)=O)[CH:5]1[CH2:11][CH2:10][CH2:9][C:8]2[CH:12]=[CH:13][C:14]([C:16](=[O:19])[NH:17][CH3:18])=[CH:15][C:7]=2[CH2:6]1.[ClH:35]>C(OCC)(=O)C>[ClH:35].[OH:1][C@H:2]([CH2:27][O:28][C:29]1[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=1)[CH2:3][NH:4][CH:5]1[CH2:11][CH2:10][CH2:9][C:8]2[CH:12]=[CH:13][C:14]([C:16](=[O:19])[NH:17][CH3:18])=[CH:15][C:7]=2[CH2:6]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 57322038HCID 57322038, compound

Product 1

HCID 69330106HCID 69330106, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

A solution of N-[(2S)-2-hydroxy-3-phenoxypropyl]-N-(3-methylcarbamoyl-6,7,8,9-tetrahydro-5H-benzocyclohepten-6-yl)-tert-butoxycarbonylamine (108 mg) in ethyl acetate (1 ml) was treated with 4N hydrogen chloride in ethyl acetate solution (0.58 ml) overnight. The mixture was evaporated in vacuo and triturated in diisopropyl ether, and the precipitated powder was collected by filtration to afford 6-[(2S)-2-hydroxy-3-phenoxypropyl]amino-3-methylcarbamoyl-6,7,8,9-tetrahydro-5H-benzocycloheptene hydrochloride (86 mg).

Workup

  1. customThe mixture was evaporated in vacuo
  2. customtriturated in diisopropyl ether
  3. filtrationthe precipitated powder was collected by filtration

Sources & evidence

ORD record
ord-489f189782dd4a1f81cdd0f6ba923fa0
Source dataset
uspto-grants-2002_12
Patent number
US06495546B1

Reaction notes

Loading…