3-Methoxybenzylamine → HCID 18375926, compound

HRID 2300735Notes

Reaction equation

HRID 2300735 reaction equation
CS([C:5]1[N:10]=[C:9]([N:11]2[C:15]3[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=3[N:13]=[CH:12]2)[CH:8]=[CH:7][N:6]=1)(=O)=O.[CH3:20][O:21][C:22]1[CH:23]=[C:24]([CH:27]=[CH:28][CH:29]=1)[CH2:25][NH2:26]>>[CH3:20][O:21][C:22]1[CH:23]=[C:24]([CH:27]=[CH:28][CH:29]=1)[CH2:25][NH:26][C:5]1[N:10]=[C:9]([N:11]2[C:15]3[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=3[N:13]=[CH:12]2)[CH:8]=[CH:7][N:6]=1

Participants

3

Reactant 2

HCID 211563-MethoxybenzylamineHCID 155496402-Methanesulfonyl-4-[benzimidazol-1-yl]pyrimidine

Product 1

HCID 18375926HCID 18375926, compound

Procedure

2-Methanesulfonyl-4-[benzimidazol-1-yl]pyrimidine was reacted with 3-methoxybenzylamine according to the procedure described in EXAMPLE 1, Step C to afford the title compound. 1H NMR (500 MHz, CDCl3): δ 0.60 (br s, 1H); 8.44 (br s, 1H); 8.08 (br s, 1H); 7.86 (d, J=8.5 Hz, 1H); 7.3-7.5 (m, 3H); 7.02 (d, J=7.6 Hz; 1H); 6.98 (s, 1H); 6.85 (m, 2H); 5.86 (br s, 1H); 4.73 (d, J=5.7 Hz, 2H); 3.82 (s, 3H).

Sources & evidence

ORD record
ord-987791d92f21406f8d379e191d82f9ae
Source dataset
uspto-grants-2002_12
Patent number
US06498165B1

Reaction notes

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