反应详情

温度

0 °C

To a solution of 3-(chlorosulfonyl)benzoic acid (1.02 g, 4.62 mmol) in CH2Cl2 (100 mL) at 0° C. was added diethylamine (2.4 mL, 23 mmol). The resulting mixture was stirred at 0° C. for 3 h then worked up by adding 2N aqueous HCl and extracting 3× with EtOAc. The combined organic was washed with brine then dried over MgSO4 and concentrated under reduced pressure. The residue was used without further purification.

1. extractionextracting 3× with EtOAc
2. washThe combined organic was washed with brine
3. dry with materialthen dried over MgSO4
4. concentrationconcentrated under reduced pressure
5. customThe residue was used without further purification