反应详情

206 g of tert-butylamine are added dropwise to a solution of 384 g of methyl 2-chlorosulfonyl-4-nitro-benzoate (Example b) in 1500 ml of ethyl acetate at 0° C. The reaction mixture is then allowed to warm up to room temperature and is stirred at this temperature for 1 hour. After washing with dilute hydrochloric acid and water, the organic phase is dried over MgSO4 and concentrated. The residue is extracted by stirring with diisopropyl ether; Yield of sulfonamide: 377.6 g; m.p.: 122-124° C.

1. washAfter washing with dilute hydrochloric acid and water
2. dry with materialthe organic phase is dried over MgSO4
3. concentrationconcentrated
4. extractionThe residue is extracted
5. stirringby stirring with diisopropyl ether