Water → HCID 18377467, compound

HRID 2300985Notes

Reaction equation

HRID 2300985 reaction equation
Cl.Br[C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([CH3:9])[N:4]=1.[CH3:10][C:11]1[CH:18]=[CH:17][C:16]([CH3:19])=[CH:15][C:12]=1[CH2:13][SH:14].[OH-:20].[Na+].O>CN(C=O)C>[CH3:10][C:11]1[CH:18]=[CH:17][C:16]([CH3:19])=[CH:15][C:12]=1[CH2:13][S:14][C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([CH3:9])[N+:4]=1[O-:20]

Participants

6

Reactant 4

HCID 962WaterHCID 14798Sodium HydroxideHCID 13178736HCID 13178736, compoundHCID 18377463HCID 18377463, compound

Product 1

HCID 18377467HCID 18377467, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A mixture of 4.48 g (0.020 mole) of 2-bromo-6-methylpyridine hydrochloride, 3.34 g (0.022 mole) of 2,5-dimethylbenzylmercaptan and 0.88 g (0.022 mole) of powdered sodium hydroxide were stirred together at room temperature in 35 ml of DMF for 3.5 hours. The reaction mixture was poured into water and the precipitate filtered off and washed with water. Yield 1.96 g or 38%.

Workup

  1. filtrationthe precipitate filtered off
  2. washwashed with water

Sources & evidence

ORD record
ord-1ea9c0952cc44cd89a892dda424cf086
Source dataset
uspto-grants-2002_12
Patent number
US06498254B1

Reaction notes

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