反应详情

温度

25 °C

To 10.5 g (0.035 mole) of 2-[(2,6-dichlorophenyl)methylthio]-3-methyl-pyridine-N-oxide (See Example 28 above) dissolved in 100 ml of methanol were added a pinch of sodium tungstate and then dropwise 4.2 ml (0.4 mole) of 50% hydrogen peroxide. The temperature was maintained at 25° C. for four hours, and then a cold solution of NaHSO3 was added slowly to destroy residual H2O2. The solid was filtered and air-dried, having a melting point of 178-181° C., yield 10 g. The elemental analysis for C,H,N; the infrared spectrum, and the NMR spectrum all supported the proposed structure.

1. customto destroy residual H2O2
2. filtrationThe solid was filtered
3. customair-dried