反应详情

Palladium chloride (100 mg) and cupric chloride dihydrate (50 mg) were added to DMF solution (30 ml) of 2-t-butoxycarbonyl-9-allyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole (1.90 g, 6.1 mmol) and stirred at room temperature for 18 hours. The reaction solution was mixed with ethyl acetate, washed with water and dried with anhydrous sodium sulfate, and then the solvent was removed by evaporation under a reduced pressure, the thus obtained residue was mixed with diisopropyl ether (20 ml) and the thus precipitated crystals were collected by filtration to obtain 1.17 g of the title compound (59% in yield).

1. washwashed with water
2. dry with materialdried with anhydrous sodium sulfate
3. customthe solvent was removed by evaporation under a reduced pressure
4. additionthe thus obtained residue was mixed with diisopropyl ether (20 ml)
5. filtrationthe thus precipitated crystals were collected by filtration