Hydrochloric Acid → HCID 18377355, compound

HRID 2301094Notes

Reaction equation

HRID 2301094 reaction equation
[ClH:1].C(OC([N:9]1[CH2:18][CH2:17][N:16]2[CH:11]([CH2:12][S:13][C:14]3[CH:22]=[CH:21][CH:20]=[CH:19][C:15]=32)[CH2:10]1)=O)(C)(C)C>C(O)(=O)C>[ClH:1].[CH2:17]1[N:16]2[CH:11]([CH2:12][S:13][C:14]3[CH:22]=[CH:21][CH:20]=[CH:19][C:15]=32)[CH2:10][NH:9][CH2:18]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 18377283HCID 18377283, compound

Product 1

HCID 18377355HCID 18377355, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A 1 ml portion of 5 N hydrochloric acid was added to acetic acid solution (10 ml) containing 0.52 g (1.70 mmol) of 3-t-butoxycarbonyl-1,2,3,4,4a,5-hexahydropyrazino[2,1-c]-1,4-benzthiazine, and the mixture was stirred overnight at room temperature and then at 60° C. for 2 hours. The solvent was removed by evaporation under a reduced pressure and the resulting residue was recrystallized from ethanol to obtain 0.36 g (88% in yield) of the title compound.

Workup

  1. waitat 60° C. for 2 hours
  2. customThe solvent was removed by evaporation under a reduced pressure
  3. customthe resulting residue was recrystallized from ethanol
  4. customto obtain

Sources & evidence

ORD record
ord-b68fe0dcff0d4d2882e6c412f0a7207e
Source dataset
uspto-grants-2002_12
Patent number
US06498251B1

Reaction notes

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