Dimethoxymethane → HCID 18377272, compound

HRID 2301110Notes

Reaction equation

HRID 2301110 reaction equation
[Cl-:1].[Cl-].[NH2:3][CH2:4][CH2:5][C:6]1[N:10]=[CH:9][NH:8][CH:7]=1.[CH3:11][O:12]COC>Cl>[OH2:12].[ClH:1].[ClH:1].[N:10]1[C:6]2[CH2:5][CH2:4][NH:3][CH2:11][C:7]=2[NH:8][CH:9]=1

Participants

4

Reactant 2

HCID 8020DimethoxymethaneHCID 178510865HCID 178510865, compound

Product 1

HCID 18377272HCID 18377272, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Conditions

Temperature
100 °C

Procedure

Histamine dichloride (5.0 g, 27 1 mol) was dissolved in concentrated hydrochloric acid (20 ml), dimethoxymethane (7.0 ml, 79 mmol) was added dropwise to the solution, and the mixture was stirred overnight at 100° C. By evaporating the solvent from the reaction solution and purifying the thus obtained crystals by their recrystallization from methanol, 4.6 g (22 mmol, 79% in yield) of the title compound was obtained.

Workup

  1. customBy evaporating the solvent from the reaction solution
  2. custompurifying the thus obtained crystals
  3. customby their recrystallization

Sources & evidence

ORD record
ord-6ba09459eb4f4cb1bb6282569cc9c50c
Source dataset
uspto-grants-2002_12
Patent number
US06498251B1

Reaction notes

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