Hydrochloric Acid → HCID 18374731, compound

HRID 2301187Notes

Reaction equation

HRID 2301187 reaction equation
[ClH:1].C(O[N:7]1[CH2:12][CH2:11][CH:10]([N:13]([CH2:16][C:17]2[N:18]=[N:19][N:20]([CH2:22][C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)[N:21]=2)[CH2:14][CH3:15])[CH2:9][CH2:8]1)(C)(C)C>CCOC(C)=O>[ClH:1].[CH2:22]([N:20]1[N:19]=[N:18][C:17]([CH2:16][N:13]([CH:10]2[CH2:9][CH2:8][NH:7][CH2:12][CH2:11]2)[CH2:14][CH3:15])=[N:21]1)[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 18374696HCID 18374696, compound

Product 1

HCID 18374731HCID 18374731, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To 4 ml of a saturated solution of hydrogen chloride in EtOAc was added 204 mg of 1-t-butyloxy-4-(N-(2-benzyl-2H-tetrazol-5-yl)methyl-N-ethylamino)-piperidine (from Step C). After 40 minutes, the solvent was evaporated under reduced pressure to give 170 mg of the title compound.

Workup

  1. customthe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-683466d0e1ae417ab4996198ce372fe2
Source dataset
uspto-grants-2002_12
Patent number
US06498161B1

Reaction notes

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