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HRID2301423

反应详情

EQUATION

反应方程式

HRID 2301423 反应方程式

REACTANTS

反应物

4
4-Chlorobenzylamine 分子结构式
HCID66036

4-Chlorobenzylamine

C7H8ClN

1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride 分子结构式
HCID2723939

1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride

C8H18ClN3

1H-Benzotriazol-1-ol--water (1/1) 分子结构式
HCID2796029

1H-Benzotriazol-1-ol--water (1/1)

C6H7N3O2

5-Fluoro-8-hydroxyquinoline-7-carboxylic acid 分子结构式
HCID18372564

5-Fluoro-8-hydroxyquinoline-7-carboxylic acid

C10H6FNO3

PRODUCTS

产物

1
HCID 18372513 分子结构式
HCID18372513

未命名化合物

收率 41.7%

AUXILIARIES

试剂、催化剂与溶剂

1
Dimethylformamide 分子结构式
溶剂HCID6228

Dimethylformamide

C3H7NO

PROCEDURE

实验过程

To a solution of 5-fluoro-8-hydroxyquinoline-7-carboxylic acid (0.311 g) of Preparation 4 and 4-chlorobenzylamine (0.219 g) in 20 mL DMF is added 1-(3-di-methylaminopropyl)-3-ethylcarbodiimide hydrochloride (0.305 g) and 1-hydroxy-benzotriazole monohydrate (0.217 g). The mixture is stirred overnight. The solution is then poured into 30 mL ice-water. The resulting solid is collected and dried. The crude product is recrystallized from EtOAc/hexanes to yield 0.207 g of the title product as an off-white solid.

WORKUP

后处理

  1. customThe resulting solid is collected
  2. customdried
  3. customThe crude product is recrystallized from EtOAc/hexanes