Urea → HCID 11612085, compound

HRID 2301518Notes

Reaction equation

HRID 2301518 reaction equation
NC(N)=O.[NH2:5][C:6]1[C:7]([OH:17])=[C:8]([S:13]([NH2:16])(=[O:15])=[O:14])[C:9]([Cl:12])=[CH:10][CH:11]=1.[CH2:18]([O:25][C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=1[N:32]=[C:33]=[O:34])[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>>[CH2:18]([O:25][C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=1[NH:32][C:33]([NH:5][C:6]1[CH:11]=[CH:10][C:9]([Cl:12])=[C:8]([S:13]([NH2:16])(=[O:15])=[O:14])[C:7]=1[OH:17])=[O:34])[C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1

Participants

4

Reactant 3

HCID 1176UreaHCID 113680593-Amino-6-chloro-2-hydroxy-benzenesulfonamideHCID 1837346476813-81-5

Product 1

HCID 11612085HCID 11612085, compoundYield 26.3%

Procedure

Following the general procedure for urea formation outlined in example 12, 3-amino-6-chloro-2-hydroxybenzenesulfonamide (52 mg, 0.23 mmol) and 2-benzyloxyphenylisocyanate (40 mg, 0.17 mmol) were coupled to form the desired urea (20 mg, 26%). EI-MS (m/z) 446.2, 448.3, 450.2 (M−).

Sources & evidence

ORD record
ord-a6b8d3a491644accaa109156c2a26cf0
Source dataset
uspto-grants-2002_12
Patent number
US06500863B1

Reaction notes

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