Thiomorpholine → HCID 18373505, compound

HRID 2301562Notes

Reaction equation

HRID 2301562 reaction equation
[Cl:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[C:4]([Cl:11])[C:3]=1[S:12](Cl)(=[O:14])=[O:13].[NH:16]1[CH2:21][CH2:20][S:19][CH2:18][CH2:17]1>C(N(CC)CC)C>[Cl:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[C:4]([Cl:11])[C:3]=1[S:12]([N:16]1[CH2:21][CH2:20][S:19][CH2:18][CH2:17]1)(=[O:14])=[O:13]

Participants

4

Reactant 2

HCID 67164ThiomorpholineHCID 234477722,6-Dichloro-3-nitrobenzene-1-sulfonyl chloride

Product 1

HCID 18373505HCID 18373505, compoundYield 94%

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

Following the general procedure for sulfonamide formation outlined in example 15, 2,6-dichloro-3-nitrobenzenesulfonyl chloride (2.0 g, 6.88mmol), thiomorpholine (710 mg, 6.88 mmol) and triethylamine(l.92mL, 13.76mmnol) were reacted to form the desired product (2.30 g, 94%). 1H NMR (MeOD-d4): δ 7.95 (d, 1H), 7.85(d, 1H), 3.68 (t, 4H), 2.69 (t, 4H).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-4d4bba97a31d4de7b5729fa21a57bfdf
Source dataset
uspto-grants-2002_12
Patent number
US06500863B1

Reaction notes

Loading…