Triethylamine → HCID 17927860, compound

HRID 2301575Notes

Reaction equation

[Cl:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[C:4]([Cl:11])[C:3]=1[S:12](Cl)(=[O:14])=[O:13].Cl.[NH:17]1[CH2:20][CH2:19][CH2:18]1.C(N(CC)CC)C>>[N:17]1([S:12]([C:3]2[C:4]([Cl:11])=[CH:5][CH:6]=[C:7]([N+:8]([O-:10])=[O:9])[C:2]=2[Cl:1])(=[O:14])=[O:13])[CH2:20][CH2:19][CH2:18]1

Participants

Reactant 3

HCID 8471Triethylamine

HCID 12308726Azetidine hydrochloride

HCID 234477722,6-Dichloro-3-nitrobenzene-1-sulfonyl chloride

Product 1

HCID 17927860HCID 17927860, compoundYield 48%

Procedure

Following the general procedure for sulfonamide formation outlined in example 15, 2,6-dichloro-3-nitrobenzenesulfonyl chloride (1.0 g, 3.44 mmol), azetidine hydrochloride (320 mg, 3.44 mmol) and triethylamine(1.44mL, 10.32 mmol) were reacted to form the desired product (510 mg, 48%). 1H NMR (MeOD-d4): δ 7.94 (d, 1H), 7.79 (d, 1H), 4.16 (t, 4H), 2.29 (m, 2H).

Workup

customwere reacted

Sources & evidence

ORD record: ord-c31bd8d63a0e4ae6824092ba3685e2a8
Source dataset: uspto-grants-2002_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06500863B1

Reaction notes

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