Water → HCID 18373486, compound

HRID 2301576Notes

Reaction equation

HRID 2301576 reaction equation
[N:1]1([S:5]([C:8]2[C:13]([Cl:14])=[CH:12][CH:11]=[C:10]([N+:15]([O-:17])=[O:16])[C:9]=2Cl)(=[O:7])=[O:6])[CH2:4][CH2:3][CH2:2]1.[H-].[Na+].[OH2:21]>>[N:1]1([S:5]([C:8]2[C:13]([Cl:14])=[CH:12][CH:11]=[C:10]([N+:15]([O-:17])=[O:16])[C:9]=2[OH:21])(=[O:7])=[O:6])[CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 3

HCID 962WaterHCID 24758Sodium hydrideHCID 17927860HCID 17927860, compound

Product 1

HCID 18373486HCID 18373486, compoundYield 50%

Procedure

Following the general hydrolysis procedure outlined in example 15, 1-(azetidin-1-yl)sulfonyl-2,6-dichloro-3-nitrobenzene (510 mg, 1.64mmol), 60% NaH (197 mg, 4.92 mmol) and water (35 μL, 1.97 mmol) were reacted to form the desired product (240 mg, 50%). 1H NMR (MeOD-d4): δ 8.09 (d, 1H), 7.25 (d, 1H), 4.15 (t, 4H), 2.29 (m, 2H).

Workup

  1. customthe general hydrolysis procedure
  2. customwere reacted

Sources & evidence

ORD record
ord-e57ea7d363374e039030731641a97546
Source dataset
uspto-grants-2002_12
Patent number
US06500863B1

Reaction notes

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