Water → HCID 18373507, compound

HRID 2301581Notes

Reaction equation

HRID 2301581 reaction equation
[CH:1]1([NH:4][S:5]([C:8]2[C:13]([Cl:14])=[CH:12][CH:11]=[C:10]([N+:15]([O-:17])=[O:16])[C:9]=2Cl)(=[O:7])=[O:6])[CH2:3][CH2:2]1.[H-].[Na+].[OH2:21]>>[CH:1]1([NH:4][S:5]([C:8]2[C:13]([Cl:14])=[CH:12][CH:11]=[C:10]([N+:15]([O-:17])=[O:16])[C:9]=2[OH:21])(=[O:7])=[O:6])[CH2:3][CH2:2]1

Participants

4

Reactant 3

HCID 962WaterHCID 24758Sodium hydrideHCID 17927831HCID 17927831, compound

Product 1

HCID 18373507HCID 18373507, compoundYield 68.3%

Procedure

Following the general hydrolysis procedure outlined in example 15, N-cyclopropyl-2,6-dichloro-3-nitrobenzenesulfonamide (1.15 g, 3.70 mmol), 60% NaH (444 mg, 11.1 mmol) and water (67 μL, 3.70 mmol) were reacted to form the desired product (740 mg, 68%). 1H NMR (MeOD-d4): δ 8.06 (d, 1H), 7.24 (d, 1H), 2.29 (m, 1H), 0.60 (m, 4H).

Workup

  1. customthe general hydrolysis procedure
  2. customwere reacted

Sources & evidence

ORD record
ord-9e36ef6d098e4508acb8e3c7d7bdfebe
Source dataset
uspto-grants-2002_12
Patent number
US06500863B1

Reaction notes

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