Water → HCID 18373450, compound

HRID 2301586Notes

Reaction equation

HRID 2301586 reaction equation
[CH2:1]([NH:4][S:5]([C:8]1[C:13]([Cl:14])=[CH:12][CH:11]=[C:10]([N+:15]([O-:17])=[O:16])[C:9]=1Cl)(=[O:7])=[O:6])[CH2:2][CH3:3].[H-].[Na+].[OH2:21]>>[CH2:1]([NH:4][S:5]([C:8]1[C:13]([Cl:14])=[CH:12][CH:11]=[C:10]([N+:15]([O-:17])=[O:16])[C:9]=1[OH:21])(=[O:7])=[O:6])[CH2:2][CH3:3]

Participants

4

Reactant 3

HCID 962WaterHCID 24758Sodium hydrideHCID 17927876HCID 17927876, compound

Product 1

HCID 18373450HCID 18373450, compoundYield 69.1%

Procedure

Following the general hydrolysis procedure outlined in example 15, N-propyl-2,6-dichloro-3-nitrobenzenesulfonamide (1.0 , 3.19mmol), 60% NaH (393 mg, 3.19 mmol) and water (58 μL, 3.19 mmol) were reacted to form the desired product (650 mg, 69%). LC-MS (m/z) 295.0 (M+).

Workup

  1. customthe general hydrolysis procedure
  2. customwere reacted

Sources & evidence

ORD record
ord-fca6f124d60a4f45b85a6937e2a9e594
Source dataset
uspto-grants-2002_12
Patent number
US06500863B1

Reaction notes

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