Water → HCID 18373485, compound

HRID 2301592Notes

Reaction equation

HRID 2301592 reaction equation
[CH2:1]([NH:3][S:4]([C:7]1[C:12]([Cl:13])=[CH:11][CH:10]=[C:9]([N+:14]([O-:16])=[O:15])[C:8]=1Cl)(=[O:6])=[O:5])[CH3:2].[H-].[Na+].[OH2:20]>>[CH2:1]([NH:3][S:4]([C:7]1[C:12]([Cl:13])=[CH:11][CH:10]=[C:9]([N+:14]([O-:16])=[O:15])[C:8]=1[OH:20])(=[O:6])=[O:5])[CH3:2]

Participants

4

Reactant 3

HCID 962WaterHCID 24758Sodium hydrideHCID 17927820HCID 17927820, compound

Product 1

HCID 18373485HCID 18373485, compound

Procedure

Following the general hydrolysis procedure outlined in example 15, N-ethyl-2,6dichloro-3-nitrobenzenesulfonamide (1.16 g, 3.88mmol), 60% NaH (466 mg, 11.64 mmol) and water (70 μL, 3.88 mmol) were reacted. The crude product (1.34 g) was carried on to the next step without purification. 1H NMR (MeOD-d4): δ 8.07 (d, 1H), 7.25 (d, 1H), 3.05 (q, 2H), 1.12 (t, 3H).

Workup

  1. customthe general hydrolysis procedure
  2. customwere reacted
  3. customThe crude product (1.34 g) was carried on to the next step without purification

Sources & evidence

ORD record
ord-ff26e2cdcc364f09ae3124a577ba6a5d
Source dataset
uspto-grants-2002_12
Patent number
US06500863B1

Reaction notes

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