Water → HCID 18373541, compound

HRID 2301602Notes

Reaction equation

HRID 2301602 reaction equation
[CH2:1]([O:8][CH2:9][CH2:10][NH:11][S:12]([C:15]1[C:20]([Cl:21])=[CH:19][CH:18]=[C:17]([N+:22]([O-:24])=[O:23])[C:16]=1Cl)(=[O:14])=[O:13])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[H-].[Na+].[OH2:28]>>[CH2:1]([O:8][CH2:9][CH2:10][NH:11][S:12]([C:15]1[C:20]([Cl:21])=[CH:19][CH:18]=[C:17]([N+:22]([O-:24])=[O:23])[C:16]=1[OH:28])(=[O:14])=[O:13])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 962WaterHCID 24758Sodium hydrideHCID 18373440HCID 18373440, compound

Product 1

HCID 18373541HCID 18373541, compoundYield 77%

Procedure

Following the general hydrolysis procedure outlined in example 15, N-(2-benzyloxyethyl)-2,6-dichloro-3-nitrobenzenesulfonamide (2.31 g, 5.71 mmol), 60% NaH (683 mg, 17.1mmol) and water (103 μ, 5.72mmol) were reacted to form the desired product (1.70 g, 77%). LC-MS (m/z) 387.5(M+).

Workup

  1. customthe general hydrolysis procedure
  2. customwere reacted

Sources & evidence

ORD record
ord-eadedfba51b549edabd6ff8752fc0ecb
Source dataset
uspto-grants-2002_12
Patent number
US06500863B1

Reaction notes

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