Water → HCID 18373547, compound

HRID 2301607Notes

Reaction equation

HRID 2301607 reaction equation
[CH:1]1([CH2:4][NH:5][S:6]([C:9]2[C:14]([Cl:15])=[CH:13][CH:12]=[C:11]([N+:16]([O-:18])=[O:17])[C:10]=2Cl)(=[O:8])=[O:7])[CH2:3][CH2:2]1.[H-].[Na+].[OH2:22]>>[Cl:15][C:14]1[C:9]([S:6]([NH:5][CH2:4][CH:1]2[CH2:3][CH2:2]2)(=[O:8])=[O:7])=[C:10]([OH:22])[C:11]([N+:16]([O-:18])=[O:17])=[CH:12][CH:13]=1

Participants

4

Reactant 3

HCID 962WaterHCID 24758Sodium hydrideHCID 17927791HCID 17927791, compound

Product 1

HCID 18373547HCID 18373547, compoundYield 72.7%

Procedure

Following the general hydrolysis procedure outlined in example 15, N-cyclopropylmethyl-2,6 dichloro-3-nitrobenzenesulfonamide (0.85 g, 2.6 mmol), 80% NaH (0.23 g, 9.88 mmol) and water (56 μL, 3.1 mmol) were reacted to form the desired product (0.58 g, 72%). LC-MS m/z 307 M+).

Workup

  1. customthe general hydrolysis procedure
  2. customwere reacted

Sources & evidence

ORD record
ord-505b7d0afe4847c18c1cd6ccd9c91d69
Source dataset
uspto-grants-2002_12
Patent number
US06500863B1

Reaction notes

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