Water → HCID 86588374, compound

HRID 2301612Notes

Reaction equation

HRID 2301612 reaction equation
[N:1]1([C:6]2[CH:11]=[C:10]([Cl:12])[C:9]([S:13]([NH2:16])(=[O:15])=[O:14])=[C:8](Cl)[C:7]=2[N+:18]([O-:20])=[O:19])[CH2:5][CH2:4][CH2:3][CH2:2]1.[H-].[Na+].[OH2:23]>>[N:1]1([C:6]2[CH:11]=[C:10]([Cl:12])[C:9]([S:13]([NH2:16])(=[O:15])=[O:14])=[C:8]([OH:23])[C:7]=2[N+:18]([O-:20])=[O:19])[CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 3

HCID 962WaterHCID 24758Sodium hydrideHCID 86588373HCID 86588373, compound

Product 1

HCID 86588374HCID 86588374, compoundYield 85.9%

Procedure

Following the general hydrolysis procedure outlined in example 15, (N-pyrrolidinyl)-2,6 dichloro-3-nitrobenzenesulfonamide (1.12 g, 3.4mmol), 80% NaH (0.31 g, 10.3 mmol) and water (74 μL, 4.1mmol) were reacted to form the desired product (0.94 g, 69%). LC-MS m/z 307(M+).

Workup

  1. customthe general hydrolysis procedure
  2. customwere reacted

Sources & evidence

ORD record
ord-67f0141eb946495099356be158607fd8
Source dataset
uspto-grants-2002_12
Patent number
US06500863B1

Reaction notes

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