Water → HCID 18373524, compound

HRID 2301615Notes

Reaction equation

HRID 2301615 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([NH:7][S:8]([C:11]2[C:16]([Cl:17])=[CH:15][CH:14]=[C:13]([N+:18]([O-:20])=[O:19])[C:12]=2Cl)(=[O:10])=[O:9])=[CH:3][CH:2]=1.[H-].[Na+].[OH2:24]>>[N:1]1[CH:6]=[CH:5][C:4]([NH:7][S:8]([C:11]2[C:16]([Cl:17])=[CH:15][CH:14]=[C:13]([N+:18]([O-:20])=[O:19])[C:12]=2[OH:24])(=[O:10])=[O:9])=[CH:3][CH:2]=1

Participants

4

Reactant 3

HCID 962WaterHCID 24758Sodium hydrideHCID 18373479HCID 18373479, compound

Product 1

HCID 18373524HCID 18373524, compoundYield 33.3%

Procedure

Following the general hydrolysis procedure outlined in example 15, N-(4-pyridinyl)-2,6-dichloro-3-nitrobenzenesulfonamide (540 mg, 1.55 mmol), 80% NaH (217 mg,7.25 mmol) and water (0.045mL, 2.46 mmol) were reacted to form the desired product (170 mg, 33%). EI-MS m/z 328(M-H)−.

Workup

  1. customthe general hydrolysis procedure
  2. customwere reacted

Sources & evidence

ORD record
ord-062d8fa13c8a4951af89bb46f2e980f8
Source dataset
uspto-grants-2002_12
Patent number
US06500863B1

Reaction notes

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