Water → HCID 18373494, compound

HRID 2301635Notes

Reaction equation

HRID 2301635 reaction equation
[CH:1]([O:4][CH2:5][CH2:6][NH:7][S:8]([C:11]1[C:16]([Cl:17])=[CH:15][CH:14]=[C:13]([N+:18]([O-:20])=[O:19])[C:12]=1Cl)(=[O:10])=[O:9])([CH3:3])[CH3:2].[H-].[Na+].[OH2:24]>>[CH:1]([O:4][CH2:5][CH2:6][NH:7][S:8]([C:11]1[C:16]([Cl:17])=[CH:15][CH:14]=[C:13]([N+:18]([O-:20])=[O:19])[C:12]=1[OH:24])(=[O:10])=[O:9])([CH3:3])[CH3:2]

Participants

4

Reactant 3

HCID 962WaterHCID 24758Sodium hydrideHCID 17927806HCID 17927806, compound

Product 1

HCID 18373494HCID 18373494, compound

Procedure

Following the general hydrolysis procedure outlined in example 15, N-(2-isopropoxyethyl)-2,6-dichloro-3-nitrobenzenesulfonamide (1.635 g, 4.58 mmol), 60% NaH (0.41 g, 13.74 mmol) and water (0.099 mL, 5.50 mmol) were reacted. The crude product (1.676 g) was carried on to the next step without purification. LC-MS (m/z) 340 (M-H)+.

Workup

  1. customthe general hydrolysis procedure
  2. customwere reacted
  3. customThe crude product (1.676 g) was carried on to the next step without purification

Sources & evidence

ORD record
ord-b6b8ab4a977d4a9281d8b2370661fc9c
Source dataset
uspto-grants-2002_12
Patent number
US06500863B1

Reaction notes

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