Water → HCID 18373452, compound

HRID 2301638Notes

Reaction equation

HRID 2301638 reaction equation
[CH2:1]([O:3][CH2:4][CH2:5][NH:6][S:7]([C:10]1[C:15]([Cl:16])=[CH:14][CH:13]=[C:12]([N+:17]([O-:19])=[O:18])[C:11]=1Cl)(=[O:9])=[O:8])[CH3:2].[H-].[Na+].[OH2:23]>>[CH2:1]([O:3][CH2:4][CH2:5][NH:6][S:7]([C:10]1[C:15]([Cl:16])=[CH:14][CH:13]=[C:12]([N+:17]([O-:19])=[O:18])[C:11]=1[OH:23])(=[O:9])=[O:8])[CH3:2]

Participants

4

Reactant 3

HCID 962WaterHCID 24758Sodium hydrideHCID 17927853HCID 17927853, compound

Product 1

HCID 18373452HCID 18373452, compound

Procedure

Following the general hydrolysis procedure outlined in example 15, N-(2-ethoxyethyl)-2,6-dichloro-3-nitrobenzenesulfonamide (1.78 g, 5.16 mmol), 80% NaH (0.46 g, 15.48mmol) and water (111 μL, 6.20mmol) were reacted. The crude product (1.63 g) was carried onto the next step without purification. LC-MS (m/z) 325.0(M+).

Workup

  1. customthe general hydrolysis procedure
  2. customwere reacted
  3. customThe crude product (1.63 g) was carried onto the next step without purification

Sources & evidence

ORD record
ord-cbfa3feee9eb45ceb31aa931910e19ba
Source dataset
uspto-grants-2002_12
Patent number
US06500863B1

Reaction notes

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