Triethylamine → HCID 18373499, compound

HRID 2301640Notes

Reaction equation

HRID 2301640 reaction equation
[Cl:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[C:4]([Cl:11])[C:3]=1[S:12](Cl)(=[O:14])=[O:13].[NH2:16][CH2:17][CH2:18][CH2:19][N:20]1[CH2:25][CH2:24][O:23][CH2:22][CH2:21]1.C(N(CC)CC)C>>[N:20]1([CH2:19][CH2:18][CH2:17][NH:16][S:12]([C:3]2[C:4]([Cl:11])=[CH:5][CH:6]=[C:7]([N+:8]([O-:10])=[O:9])[C:2]=2[Cl:1])(=[O:14])=[O:13])[CH2:25][CH2:24][O:23][CH2:22][CH2:21]1

Participants

4

Reactant 3

HCID 8471TriethylamineHCID 61055N-(3-Aminopropyl)morpholineHCID 234477722,6-Dichloro-3-nitrobenzene-1-sulfonyl chloride

Product 1

HCID 18373499HCID 18373499, compoundYield 74.5%

Procedure

Following the general procedure for sulfonamide formation outlined in example 15, 2,6-dichloro-3-nitrobenzenesulfonyl chloride (2.0 g, 6.88 mmol), 4-(3-aminopropyl)morpholine (993 mg, 6.88 mmol) and triethylamine(1.92 mL, 13.76 mmol) were reacted to form the desired product (2.04 g, 74%). LC-MS (m/z) 398.0 (M+).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-b563cd10b2da435f85aa47722b8bc8ed
Source dataset
uspto-grants-2002_12
Patent number
US06500863B1

Reaction notes

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