Hydrochloric Acid → HCID 18373533, compound

HRID 2301641Notes

Reaction equation

HRID 2301641 reaction equation
[N:1]1([CH2:7][CH2:8][CH2:9][NH:10][S:11]([C:14]2[C:19]([Cl:20])=[CH:18][CH:17]=[C:16]([N+:21]([O-:23])=[O:22])[C:15]=2Cl)(=[O:13])=[O:12])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[H-].[Na+].[OH2:27].Cl>O1CCOCC1>[N:1]1([CH2:7][CH2:8][CH2:9][NH:10][S:11]([C:14]2[C:19]([Cl:20])=[CH:18][CH:17]=[C:16]([N+:21]([O-:23])=[O:22])[C:15]=2[OH:27])(=[O:13])=[O:12])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 24758Sodium hydrideHCID 18373499HCID 18373499, compound

Product 1

HCID 18373533HCID 18373533, compoundYield 105.9%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Following the general hydrolysis procedure outlined in example 15, N-[3-(4-morpholinyl)propyl]-2,6-dichloro-3-nitrobenzenesulfonamide (10 g, 2.51 mmol), 60% NaH (301 mg, 7.53 mmol) and water (54 μL, 3.0 mmol) were reacted. The mixture was acidified with 4.ON HCl in 1,4-dioxane and concentrated to give the crude product (1.01 g), which was carried onto the next steps without purification. LC-MS 380.0 (M+).

Workup

  1. customthe general hydrolysis procedure
  2. customwere reacted
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-88dfd21099d145f799d26d03469a8cda
Source dataset
uspto-grants-2002_12
Patent number
US06500863B1

Reaction notes

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