Water → HCID 18373434, compound

HRID 2301644Notes

Reaction equation

HRID 2301644 reaction equation
[C:1]([NH:5][S:6]([C:9]1[C:14]([Cl:15])=[CH:13][CH:12]=[C:11]([N+:16]([O-:18])=[O:17])[C:10]=1Cl)(=[O:8])=[O:7])([CH3:4])([CH3:3])[CH3:2].[H-].[Na+].[OH2:22]>>[C:1]([NH:5][S:6]([C:9]1[C:14]([Cl:15])=[CH:13][CH:12]=[C:11]([N+:16]([O-:18])=[O:17])[C:10]=1[OH:22])(=[O:8])=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 3

HCID 962WaterHCID 24758Sodium hydrideHCID 17927834HCID 17927834, compound

Product 1

HCID 18373434HCID 18373434, compound

Procedure

Following the general hydrolysis procedure outlined in example 15, N-(tert-butyl)-2,6-dichloro-3-nitrobenzenesulfonamide (1.67 g, 5.1 mmol), 60% NaH (612 mg, 15.3 mmol) and water (92 μL, 5l mmol) were reacted to form the crude product (1.54 g), which was carried on to the next step without purification. 1H NMR (MeOD-d4): δ 8.00 (d, 1H), 7.08 (d, 1H), 1.24 (s, 9H).

Workup

  1. customthe general hydrolysis procedure
  2. customwere reacted

Sources & evidence

ORD record
ord-f48064e7ce1146a5926a904f6291b620
Source dataset
uspto-grants-2002_12
Patent number
US06500863B1

Reaction notes

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