Triethylamine → HCID 18373469, compound

HRID 2301656Notes

Reaction equation

HRID 2301656 reaction equation
[Cl:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[C:4]([Cl:11])[C:3]=1[S:12](Cl)(=[O:14])=[O:13].[NH2:16][CH2:17][CH:18]1[CH2:22][CH2:21][CH2:20][N:19]1[CH2:23][CH3:24].C(N(CC)CC)C>>[CH2:23]([N:19]1[CH2:20][CH2:21][CH2:22][CH:18]1[CH2:17][NH:16][S:12]([C:3]1[C:4]([Cl:11])=[CH:5][CH:6]=[C:7]([N+:8]([O-:10])=[O:9])[C:2]=1[Cl:1])(=[O:14])=[O:13])[CH3:24]

Participants

4

Reactant 3

HCID 8471TriethylamineHCID 1172952-Aminomethyl-1-ethylpyrrolidineHCID 234477722,6-Dichloro-3-nitrobenzene-1-sulfonyl chloride

Product 1

HCID 18373469HCID 18373469, compound

Procedure

Following the general procedure for sulfonamide formation outlined in example 15, 2,6-dichloro-3-nitrobenzenesulfonyl chloride (2.0 g, 6.88 mmol), 2-aminomethyl- 1-ethyl-pyrolidine (882 mg, 6.88 mmol) and triethylamine(1.92 mL, 13.76 mmol) were reacted. The crude product (2.64 g) was carried on to the next step without purification. LC-MS (m/z) 382.0 (M+).

Workup

  1. customwere reacted
  2. customThe crude product (2.64 g) was carried on to the next step without purification

Sources & evidence

ORD record
ord-972e8c10cea74f21a2152b6f3f10f251
Source dataset
uspto-grants-2002_12
Patent number
US06500863B1

Reaction notes

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