Sertraline → Sertraline Hydrochloride

HRID 2301714Notes

Reaction equation

HRID 2301714 reaction equation
[CH3:1][NH:2][C@@H:3]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[C@H:6]([C:13]2[CH:14]=[CH:15][C:16]([Cl:20])=[C:17]([Cl:19])[CH:18]=2)[CH2:5][CH2:4]1>C1(C)C=CC=CC=1>[CH3:1][NH:2][C@@H:3]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[C@H:6]([C:13]2[CH:14]=[CH:15][C:16]([Cl:20])=[C:17]([Cl:19])[CH:18]=2)[CH2:5][CH2:4]1.[ClH:19]

Participants

3

Reactant 1

HCID 68617Sertraline

Product 1

HCID 63009Sertraline HydrochlorideYield 203.7%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

Sertraline base (5.8 gr.) was dissolved in toluene (200 mL). HCl gas was bubbled (about pH 1.5) through the solution. A gel is formed. Filtration and drying at 50° C. for 16 hours gives amorphous sertraline hydrochloride (6.61 gr.).

Workup

  1. customHCl gas was bubbled (about pH 1.5) through the solution
  2. customA gel is formed
  3. filtrationFiltration
  4. customdrying at 50° C. for 16 hours

Sources & evidence

ORD record
ord-74085f067c824adaa2cf6b17fa5febc0
Source dataset
uspto-grants-2002_12
Patent number
US06500987B1

Reaction notes

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