反应详情

Using the method of Dodd (Synthesis, 1993, 295-297), a solution of 6-fluoroquinoxaline-2-carboxaldehyde (71 mg, 0.4 mmol) in formic acid (2 mL) was cooled in an ice bath and treated with hydrogen peroxide (2 mL of 30%). The reaction was stirred in the ice bath for 3 hours. After this time the reaction mixture was diluted with 10% HCl (25 mL) and extracted with dichloromethane (4×25 mL). The combined organic extracts were dried over anhydrous MgSO4, filtered and concentrated to afford 35 mg (45%) of 6-fluoroquinoxaline-2-carboxylic acid.

1. customthe method of Dodd (Synthesis, 1993, 295-297)
2. extractionextracted with dichloromethane (4×25 mL)
3. dry with materialThe combined organic extracts were dried over anhydrous MgSO4
4. filtrationfiltered
5. concentrationconcentrated