Methanol → 1,3-Bis(1-hydroxyethyl)adamantane

HRID 2302109노트

반응식

HRID 2302109 반응식
[BH4-].[Na+].[C:3]([C:6]12[CH2:15][CH:10]3[CH2:11][CH:12]([CH2:14][C:8]([C:16](=[O:18])[CH3:17])([CH2:9]3)[CH2:7]1)[CH2:13]2)(=[O:5])[CH3:4].CO.[OH-].[Na+]>O>[OH:5][CH:3]([C:6]12[CH2:15][CH:10]3[CH2:11][CH:12]([CH2:14][C:8]([CH:16]([OH:18])[CH3:17])([CH2:9]3)[CH2:7]1)[CH2:13]2)[CH3:4]

참가 물질

6

반응물 4

HCID 887MethanolHCID 14798Sodium HydroxideHCID 28432551,3-DiacetyladamantaneHCID 4311764Sodium borohydride

생성물 1

HCID 40384941,3-Bis(1-hydroxyethyl)adamantane수율 96.4%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A total of 1 g of sodium borohydride was slowly added to a mixture of 5.6 g of 1,3-diacetyladamantane, 20 ml of methanol, and 3 ml of 0.1 N sodium hydroxide aqueous solution on a water bath. After stirring for 30 minutes at room temperature, the resultant mixture was neutralized with a 1 N hydrochloric ac4d aqueous solution. To the neutralized mixture was added 50 ml of water, and the resultant mixture was extracted with three portions of 100 ml of ethyl acetate. The obtained organic layer was concentrated to give 5.5 g of 1,3-bis(1-hydroxyethyl)adamantane.

후처리

  1. extractionthe resultant mixture was extracted with three portions of 100 ml of ethyl acetate
  2. concentrationThe obtained organic layer was concentrated

출처 및 근거

ORD 기록
ord-0dcd1e026153431691d2c7cf401103ef
출처 데이터셋
uspto-grants-2002_08
특허 번호
US06429314B1

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