反应详情

The reaction product from stage f and 27.6 g of potassium carbonate are stirred at room temperature for 16 hours in 80 ml of dimethylformamide. The reaction mixture is then added to 750 ml of ice water, and the solid is filtered off with suction and washed with 80 ml of cold methanol. After drying, 47 g of ethyl 8-cyano-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate of melting point 209-211° C. are obtained.

1. filtrationthe solid is filtered off with suction
2. washwashed with 80 ml of cold methanol
3. customAfter drying