3-Bromothiophene → HCID 11393857, compound

HRID 230266Notes

Reaction equation

HRID 230266 reaction equation
[CH3:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([C:8]([CH2:18][CH:19]=[O:20])=[C:9]([C:11]3[CH:16]=[CH:15][C:14]([CH3:17])=[CH:13][CH:12]=3)[N:10]=2)[CH:7]=1.Br[C:22]1[CH:26]=[CH:25][S:24][CH:23]=1>>[CH3:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([C:8]([CH2:18][C:19]([C:22]3[CH:26]=[CH:25][S:24][CH:23]=3)=[O:20])=[C:9]([C:11]3[CH:16]=[CH:15][C:14]([CH3:17])=[CH:13][CH:12]=3)[N:10]=2)[CH:7]=1

Participants

3

Reactant 2

HCID 133833-BromothiopheneHCID 57444052(6-Methyl-2-p-tolyl-imidazo[1,2-a]pyridin-3-yl)-acetaldehyde

Product 1

HCID 11393857HCID 11393857, compound

Procedure

Prepared from (6-methyl-2-p-tolyl-imidazo[1,2-a]pyridine-3-yl)-acetaldehyde 6b and 3-bromo-thiophene using the procedure of Method B described above. 1H NMR (400 MHz, CDCl3) δ 2.33 (s, 3H), 2.41 (s, 3H), 4.60 (s, 2H), 7.05 (dd, J=1.4 Hz, 9.1 Hz, 1H), 7.30 (m, 4H), 7.53 (d, J=1.4 Hz, 1H), 7.55 (d, J=8.0 Hz, 2H), 7.59 (s, 1H), 7.99 (d, J=1.1, 2.5 Hz, 1H). Mass spectrum (m/e) 347 (M+).

Sources & evidence

ORD record
ord-1a139b6e4d7340b089a393be72222a86
Source dataset
uspto-grants-2009_07
Patent number
US07566725B2

Reaction notes

Loading…