Water → HCID 18618217, compound

HRID 2303289Notes

Reaction equation

HRID 2303289 reaction equation
[C:1](Cl)(=[O:3])[CH3:2].[Br:5][C:6]1[C:10]2[N:11]=[CH:12][N:13]([OH:16])[C:14](=[O:15])[C:9]=2[S:8][CH:7]=1.O>O1CCCC1.N1C=CC=CC=1.CN1CCCC1=O>[C:1]([O:16][N:13]1[C:14](=[O:15])[C:9]2[S:8][CH:7]=[C:6]([Br:5])[C:10]=2[N:11]=[CH:12]1)(=[O:3])[CH3:2]

Participants

7

Reactant 3

HCID 962WaterHCID 6367Acetyl chlorideHCID 18460853HCID 18460853, compound

Product 1

HCID 18618217HCID 18618217, compound

Reagents, catalysts & solvents 3

HCID 1049PyridineSolventHCID 8028TetrahydrofuranSolventHCID 13387N-methyl-2-pyrrolidoneSolvent

Procedure

To a solution of acetyl chloride (0.234 g) in dry tetrahydrofuran (3 ml) was added a solution of the product from Example 4 (0.741 g) in pyridine (0.237 g) and N-methylpyrrolidone (5 ml) at room temperature. The solution was stirred at room temperature for 3 days and then poured into water (15 ml). The resulting precipitate was filtered, washed with water and dried to give title product, m.p. 159-162° C.

Workup

  1. filtrationThe resulting precipitate was filtered
  2. washwashed with water
  3. customdried

Sources & evidence

ORD record
ord-a33c33a9480f4696b9a569588a7f248a
Source dataset
uspto-grants-2002_08
Patent number
US06432964B1

Reaction notes

Loading…