Sodium Hydroxide → HCID 18461100, compound

HRID 2303329Notes

Reaction equation

HRID 2303329 reaction equation
C(OC([N:6]1[CH:11]2[CH:12]([O:14]C3CCCCO3)[CH2:13][CH:7]1[CH2:8][CH:9]([CH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)[CH2:10]2)=O)C.C[Si](I)(C)C.[OH-].[Na+].S([O-])([O-])=O.[Na+].[Na+]>C(Cl)(Cl)Cl>[CH2:21]([CH:9]1[CH2:10][CH:11]2[NH:6][CH:7]([CH2:13][CH:12]2[OH:14])[CH2:8]1)[C:22]1[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=1

Participants

6

Reactant 4

HCID 14798Sodium HydroxideHCID 24437Sodium SulfiteHCID 85247Trimethylsilyl iodideHCID 22958908HCID 22958908, compound

Product 1

HCID 18461100HCID 18461100, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

A solution of the 3-benzyl-6-(tetrahydro-pyran-2-yloxy)-8-aza-bicyclo[3.2.1]octane-8-carboxylic acid ethyl ester and 0.5 mL of trimethylsilyl iodide in 25 mL of chloroform was kept at room temperature for 48 h, shaken with 25 mL of 6N NaOH and dilute sodium sulfite and dried over magnesium sulfate. Removal of solvents gave 0.2 g of a resin.

Workup

  1. dry with materialdried over magnesium sulfate
  2. customRemoval of solvents

Sources & evidence

ORD record
ord-938313be508d4345beaefbe01d0dc735
Source dataset
uspto-grants-2002_08
Patent number
US06432976B1

Reaction notes

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