4-Chloromethyl-2-(3,4,5-trimethoxyphenyl) pyridine → Hydrochloric Acid

HRID 2303366Notes

Reaction equation

HRID 2303366 reaction equation
[CH:1]([C@H:4]1[NH:9][CH2:8][CH2:7][N:6]([CH2:10][C:11]2[CH:16]=[CH:15][N:14]=[C:13]([C:17]3[CH:22]=[C:21]([O:23][CH3:24])[C:20]([O:25][CH3:26])=[C:19]([O:27][CH3:28])[CH:18]=3)[CH:12]=2)[C:5]1=[O:29])([CH3:3])[CH3:2].[Cl:30][CH2:31][C:32]1[CH:37]=[CH:36][N:35]=[C:34]([C:38]2[CH:43]=[C:42]([O:44][CH3:45])[C:41]([O:46][CH3:47])=[C:40]([O:48][CH3:49])[CH:39]=2)[CH:33]=1>>[ClH:30].[ClH:30].[ClH:30].[CH:1]([C@H:4]1[N:9]([CH2:31][C:32]2[CH:37]=[CH:36][N:35]=[C:34]([C:38]3[CH:43]=[C:42]([O:44][CH3:45])[C:41]([O:46][CH3:47])=[C:40]([O:48][CH3:49])[CH:39]=3)[CH:33]=2)[CH2:8][CH2:7][N:6]([CH2:10][C:11]2[CH:16]=[CH:15][N:14]=[C:13]([C:17]3[CH:22]=[C:21]([O:23][CH3:24])[C:20]([O:25][CH3:26])=[C:19]([O:27][CH3:28])[CH:18]=3)[CH:12]=2)[C:5]1=[O:29])([CH3:3])[CH3:2].[ClH:30]

Participants

4

Reactant 2

HCID 120192374-Chloromethyl-2-(3,4,5-trimethoxyphenyl) pyridineHCID 12019241HCID 12019241, compound

Product 2

HCID 313Hydrochloric AcidHCID 69351740HCID 69351740, compound

Procedure

(3R)-3-Isopropyl-2-oxo-1-[[2-(3,4,5-trimethoxy-phenyl)pyridin-4-yl]methyl]piperazine (109 mg) and 4-chloromethyl-2-(3,4,5-trimethoxyphenyl)pyridine (104 mg) were reacted in the same manner as in Example 4 to obtain the title compound as a hydrochloride.

Sources & evidence

ORD record
ord-c36b7c8d98e04d4281e169c8e39fe97f
Source dataset
uspto-grants-2002_08
Patent number
US06432957B1

Reaction notes

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