Iodoethane → HCID 86587906, compound

HRID 2303551Notes

Reaction equation

HRID 2303551 reaction equation
[F:1][C:2]1[CH:9]=[C:8]([OH:10])[CH:7]=[CH:6][C:3]=1[C:4]#N.[CH2:11](I)[CH3:12].[C:14]([NH:18][OH:19])([CH3:17])([CH3:16])[CH3:15]>>[F:1][C:2]1[CH:9]=[C:8]([O:10][CH2:11][CH3:12])[CH:7]=[CH:6][C:3]=1[CH:4]=[N+:18]([C:14]([CH3:17])([CH3:16])[CH3:15])[O-:19]

Participants

4

Reactant 3

HCID 6340IodoethaneHCID 98586N-tert-butylhydroxylamineHCID 27346752-Fluoro-4-hydroxybenzonitrile

Product 1

HCID 86587906HCID 86587906, compound

Procedure

The title compound was prepared according to the procedure described in Example 29 using 2-fluoro-4-hydroxybenzonitrile, ethyl iodide and N-tert-butylhydroxylamine. The title compound was isolated in 64.7% overall yield as slightly yellowish crystals. m.p. 82.5° C. (Rf=0.16 on a silica gel plate using hexanes/ethyl acetate, 4:1, v:v, as the eluant).

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-a367528e23a846f38674a56b75b906c2
Source dataset
uspto-grants-2002_08
Patent number
US06433008B1

Reaction notes

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