Dimethylformamide dimethyl acetal → HCID 72751262, compound

HRID 2303580Notes

Reaction equation

HRID 2303580 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH3:8])=[C:4]([N+:9]([O-:11])=[O:10])[CH:3]=1.CO[CH:14](OC)[N:15]([CH3:17])[CH3:16]>CN(C=O)C>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]=[CH:14][N:15]([CH3:17])[CH3:16])=[C:4]([N+:9]([O-:11])=[O:10])[CH:3]=1

Participants

4

Reactant 2

HCID 78373Dimethylformamide dimethyl acetalHCID 1235464-Bromo-2-nitrotoluene

Product 1

HCID 72751262HCID 72751262, compoundYield 106.2%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A solution of 27 grams (0.125 moles) of 4-bromo-1-methyl-2-nitrobenzene and 1 ml (.31 moles of N,N-dimethylformamide dimethyl acetal in 120 ml of DMF was heated at 80° for 2 hours. After cooling, the reaction was poured onto water and extracted with ethylacetate. Then was dried over sodium sulfate and evaporated to give 36 grams of the titled compound as a purple solid.

Workup

  1. temperatureAfter cooling
  2. additionthe reaction was poured onto water
  3. extractionextracted with ethylacetate
  4. dry with materialThen was dried over sodium sulfate
  5. customevaporated

Sources & evidence

ORD record
ord-18c62006f5a64ecdac2cf7c7f7155a81
Source dataset
uspto-grants-2002_08
Patent number
US06433009B1

Reaction notes

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