Hydrochloric Acid → HCID 18187862, compound

HRID 2303620Notes

Reaction equation

HRID 2303620 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][CH2:15][CH2:16][C:17]2[CH:18]=[N:19][C:20]3[C:25]([CH:26]=2)=[CH:24][CH:23]=[CH:22][CH:21]=3)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:27]>CO>[ClH:27].[ClH:27].[N:19]1[C:20]2[C:25](=[CH:24][CH:23]=[CH:22][CH:21]=2)[CH:26]=[C:17]([CH2:16][CH2:15][CH2:14][CH:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)[CH:18]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 18187735HCID 18187735, compound

Product 1

HCID 18187862HCID 18187862, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 1-(t-butoxycarbonyl)-4-(3-(quinolin-3-yl)propyl)piperidine from Step A (240 mg, 0.68 mmol) in 1M HCl solution (8 mL) in methanol was stirred at rt for 48 h. The solution was concentrated and the residue crystallized from ethyl acetate to afford the title compound (182 mg),

Workup

  1. concentrationThe solution was concentrated
  2. customthe residue crystallized from ethyl acetate

Sources & evidence

ORD record
ord-44d94733aea946cd8f6141f524c11e29
Source dataset
uspto-grants-2002_08
Patent number
US06432981B1

Reaction notes

Loading…