HCID 178444001, compound → 1-(4-(3-bromophenyl)-1H-imidazol-2-yl)-5-methyl-1-hexanamine

HRID 230385Notes

Reaction equation

HRID 230385 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([C:8]2[N:9]=[C:10]([CH:13]([NH:20]C(=O)OC(C)(C)C)[CH2:14][CH2:15][CH2:16][CH:17]([CH3:19])[CH3:18])[NH:11][CH:12]=2)[CH:5]=[CH:6][CH:7]=1>C(OCC)(=O)C.Cl>[Br:1][C:2]1[CH:3]=[C:4]([C:8]2[N:9]=[C:10]([CH:13]([NH2:20])[CH2:14][CH2:15][CH2:16][CH:17]([CH3:18])[CH3:19])[NH:11][CH:12]=2)[CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 1

HCID 178444001HCID 178444001, compound

Product 1

HCID 1784439681-(4-(3-bromophenyl)-1H-imidazol-2-yl)-5-methyl-1-hexanamineYield 97%

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 8857Ethyl AcetateSolvent

Procedure

tert-Butyl 1-(4-(3-bromophenyl)-1H-imidazol-2-yl)-5-methylhexylcarbamate (obtained at stage 13777.2; 3.5 g; 0.008 mol) was agitated in 120 ml of an ethyl acetate solution saturated in hydrochloric acid for about 2.5 at a temperature of about 55° C. The solid obtained was filtered and washed with ether. A white powder was obtained with a yield of 97%. Melting point: 200-202° C. MH+=336.2.

Workup

  1. customThe solid obtained
  2. filtrationwas filtered
  3. washwashed with ether
  4. customA white powder was obtained with a yield of 97%

Sources & evidence

ORD record
ord-fcabaecc975343fc8f79a06e8a13e042
Source dataset
uspto-grants-2009_07
Patent number
US07566734B2

Reaction notes

Loading…