Sodium hydride → HCID 18461493, compound

HRID 2303857Notes

Reaction equation

HRID 2303857 reaction equation
[CH2:1]1[N:6]([C:7]2[C:12]([OH:13])=[CH:11][CH:10]=[CH:9][CH:8]=2)[CH2:5][CH2:4][O:3][CH2:2]1.Cl[C:15]1[CH:16]=[CH:17][C:18]([N+:30]([O-:32])=[O:31])=[C:19]([N:21]([CH3:29])[C:22](=[O:28])[O:23][C:24]([CH3:27])([CH3:26])[CH3:25])[CH:20]=1.[H-].[Na+]>CN(C)C=O>[N:6]1([C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][C:12]=2[O:13][C:15]2[CH:16]=[CH:17][C:18]([N+:30]([O-:32])=[O:31])=[C:19]([N:21]([CH3:29])[C:22](=[O:28])[O:23][C:24]([CH3:25])([CH3:26])[CH3:27])[CH:20]=2)[CH2:1][CH2:2][O:3][CH2:4][CH2:5]1

Participants

5

Reactant 3

HCID 24758Sodium hydrideHCID 27953942-morpholinophenolHCID 15544598tert-butyl N-(5-chloro-2-nitrophenyl)-N-methylcarbamate

Product 1

HCID 18461493HCID 18461493, compoundYield 83.6%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

By using 0.72 g of 2-(4-morpholino)phenol, 1.15 g of t-butyl N-(5-chloro-2-nitrophenyl)-N-methylcarbamate, 0.17 g of sodium hydride (55% by weight) and 10 ml of anhydrous N,N-dimethylformamide, reaction and purification were carried out in a similar manner to that described in Reference Example 6, whereby 1.44 g of the title compound were obtained.

Sources & evidence

ORD record
ord-04434e18e0f548d28316e6206b5e5292
Source dataset
uspto-grants-2002_08
Patent number
US06432993B1

Reaction notes

Loading…