HCID 18461327, compound → HCID 18461433, compound

HRID 2303884Notes

Reaction equation

HRID 2303884 reaction equation
[N:1]1([C:6]2[CH:30]=[CH:29][C:9]([O:10][C:11]3[CH:12]=[CH:13][C:14]([N+:26]([O-])=O)=[C:15]([N:17]([CH3:25])[C:18](=[O:24])[O:19][C:20]([CH3:23])([CH3:22])[CH3:21])[CH:16]=3)=[CH:8][CH:7]=2)[CH:5]=[CH:4][N:3]=[CH:2]1>[Pd].CN(C)C=O>[NH2:26][C:14]1[CH:13]=[CH:12][C:11]([O:10][C:9]2[CH:8]=[CH:7][C:6]([N:1]3[CH:5]=[CH:4][N:3]=[CH:2]3)=[CH:30][CH:29]=2)=[CH:16][C:15]=1[N:17]([CH3:25])[C:18](=[O:24])[O:19][C:20]([CH3:21])([CH3:22])[CH3:23]

Participants

4

Reactant 1

HCID 18461327HCID 18461327, compound

Product 1

HCID 18461433HCID 18461433, compoundYield 69.9%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 6228DimethylformamideSolvent

Procedure

In a similar manner to that described in Reference Example 7, a reaction was carried out using t-butyl N-{5-[4-(imidazole-1-yl)phenoxy]-2-nitrophenyl]-N-methylcarbamate (8.8 g), palladium on carbon (10%, 0.8 g) and N,N-dimethylformamide (160 ml) and the reaction mixture was purified to give the title compound (5.7 g).

Workup

  1. customthe reaction mixture was purified

Sources & evidence

ORD record
ord-0beba9cf984e4e28aadd8a3fb762c356
Source dataset
uspto-grants-2002_08
Patent number
US06432993B1

Reaction notes

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