2,4-Dihydroxybenzophenone → HCID 18461485, compound

HRID 2303896Notes

Reaction equation

HRID 2303896 reaction equation
[OH:1][C:2]1[CH:15]=[C:14]([OH:16])[CH:13]=[CH:12][C:3]=1[C:4]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)=[O:5].Cl[C:18]1[CH:19]=[CH:20][C:21]([N+:33]([O-:35])=[O:34])=[C:22]([N:24]([CH3:32])[C:25](=[O:31])[O:26][C:27]([CH3:30])([CH3:29])[CH3:28])[CH:23]=1.[H-].[Na+]>CN(C)C=O>[C:4]([C:3]1[CH:12]=[CH:13][C:14]([O:16][C:18]2[CH:19]=[CH:20][C:21]([N+:33]([O-:35])=[O:34])=[C:22]([N:24]([CH3:32])[C:25](=[O:31])[O:26][C:27]([CH3:28])([CH3:29])[CH3:30])[CH:23]=2)=[CH:15][C:2]=1[OH:1])(=[O:5])[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1

Participants

5

Reactant 3

HCID 85722,4-DihydroxybenzophenoneHCID 24758Sodium hydrideHCID 15544598tert-butyl N-(5-chloro-2-nitrophenyl)-N-methylcarbamate

Product 1

HCID 18461485HCID 18461485, compoundYield 22.6%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

In a similar manner to that described in Reference Example 6, a reaction was carried out using 2,4-dihydroxybenzophenone (4.5 g), t-butyl N-(5-chloro-2-nitrophenyl)-N-methylcarbamate (6.0 g), sodium hydride (55 wt. %, 1.75 g) and anhydrous N,N-dimethylformamide (130 ml) and the reaction mixture was purified to give the title compound (2.2 g).

Workup

  1. customthe reaction mixture was purified

Sources & evidence

ORD record
ord-ecdf1f1f5ea8426a932e33986bebaf87
Source dataset
uspto-grants-2002_08
Patent number
US06432993B1

Reaction notes

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