HCID 18461285, compound → HCID 18461424, compound

HRID 2303910Notes

Reaction equation

HRID 2303910 reaction equation
[CH3:1][N:2]([C:10]1[CH:15]=[C:14]([O:16][C:17]2[CH:22]=[CH:21][C:20]([C:23]3[N:24]=[N:25][N:26]([C:28]([C:41]4[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=4)([C:35]4[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=4)[C:29]4[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=4)[N:27]=3)=[CH:19][CH:18]=2)[CH:13]=[CH:12][C:11]=1[N+:47]([O-])=O)[C:3](=[O:9])[O:4][C:5]([CH3:8])([CH3:7])[CH3:6]>[Pd].C(OCC)(=O)C>[CH3:1][N:2]([C:10]1[CH:15]=[C:14]([O:16][C:17]2[CH:22]=[CH:21][C:20]([C:23]3[N:24]=[N:25][N:26]([C:28]([C:29]4[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=4)([C:41]4[CH:42]=[CH:43][CH:44]=[CH:45][CH:46]=4)[C:35]4[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=4)[N:27]=3)=[CH:19][CH:18]=2)[CH:13]=[CH:12][C:11]=1[NH2:47])[C:3](=[O:9])[O:4][C:5]([CH3:8])([CH3:6])[CH3:7]

Participants

4

Reactant 1

HCID 18461285HCID 18461285, compound

Product 1

HCID 18461424HCID 18461424, compoundYield 74.9%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

In a similar manner to that described in Reference Example 7, a reaction was carried out using t-butyl N-methyl-N-{2-nitro-5-[4-(2-triphenylmethyltetrazol-5-yl)phenoxy]phenyl}carbamate (0.98 g), palladium on carbon (10%, 0.13 g) and ethyl acetate (100 ml) and the reaction mixture was purified to give the title compound (0.70 g).

Workup

  1. customthe reaction mixture was purified

Sources & evidence

ORD record
ord-3fdd12fcd4954ea1adaecde44fdc6449
Source dataset
uspto-grants-2002_08
Patent number
US06432993B1

Reaction notes

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