Hydrochloric Acid → HCID 18461445, compound

HRID 2303914Notes

Reaction equation

HRID 2303914 reaction equation
[OH-].[K+].C([O:6][C:7]1[CH:12]=[C:11]([C:13]([CH3:16])([CH3:15])[CH3:14])[C:10]([O:17][CH2:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)=[CH:9][C:8]=1[C:25]([CH3:28])([CH3:27])[CH3:26])(=O)C.Cl>CO>[CH2:18]([O:17][C:10]1[C:11]([C:13]([CH3:14])([CH3:15])[CH3:16])=[CH:12][C:7]([OH:6])=[C:8]([C:25]([CH3:28])([CH3:27])[CH3:26])[CH:9]=1)[C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 18461312HCID 18461312, compound

Product 1

HCID 18461445HCID 18461445, compoundYield 99.6%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of potassium hydroxide (1.51 g) in methanol (12 ml) was added 4-benzyloxy-2,5-di-t-butylphenyl acetate (4.9 g). The mixture was allowed to stand at ambient temperature overnight. The reaction mixture was neutralized with dilute hydrochloric acid and then extracted with ethyl acetate. The ethyl acetate solution was dried over anhydrous sodium sulfate and evaporated to dryness to give the title compound (4.3 g).

Workup

  1. extractionextracted with ethyl acetate
  2. dry with materialThe ethyl acetate solution was dried over anhydrous sodium sulfate
  3. customevaporated to dryness

Sources & evidence

ORD record
ord-ccba7ba01f2b4a9eba7f73a10f0c23e5
Source dataset
uspto-grants-2002_08
Patent number
US06432993B1

Reaction notes

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