反应详情

To a stirred solution of 5-methoxy-1-(4-iodobutyl)indole-3-carboxaldehyde in toluene at reflux under argon is added dropwise over 2 h a solution of 1,1′-azobis(cyclohexanecarbonitrile) and tri-n-butyltin hydride in toluene. The mixture is stirred for 3 h, cooled to room temperature, and potassium fluoride and water are added. The mixture is stirred for 18 h and filtered through a pad of kieselguhr. The filter-cake is washed (ethyl acetate) and the filtrate is concentrated in vacuo and purified by column chromatography to give the product.

1. stirringThe mixture is stirred for 18 h
2. filtrationfiltered through a pad of kieselguhr
3. washThe filter-cake is washed (ethyl acetate)
4. concentrationthe filtrate is concentrated in vacuo
5. custompurified by column chromatography
6. customto give the product